Daptomycin Rokitan 350 mg / Daptomycin Rokitan 500 mg
Properties and administration
Daptomycin® Rokitan, a semi-synthetic cyclic lipopeptide is a relatively new antibiotic, which shows strong efficacy against gram-positive bacteria. It is presented as a dry-powder vial, containing 350 mg or 500 mg. The regular infusion time is at least 30 minutes and the dosage, according to the indication is 4–6 mg/kg, every 24 hours. The half-life time is ca. 8 hours. Daptomycin® Rokitan is bactericidal and the serum concentration is linear when given once daily. The excretion of Daptomycin® Rokitan is predominantly renal.
For comprehensive details on the indications, please refer to the information for healthcare professionals.
Anti-microbial spectrum of activity and Indications
Daptomycin® Rokitan is only effective against gram-positive bacteria, the spectrum of activity includes methicillin-sensitive and -resistant Staphylococcus aureus (MSSA/MRSA), as well as vancomycin-resistant enterococci. .[1]
The approved indications are:
- Complicated skin and soft tissue infections (in adults and children and adolescents aged one to 17 years)
- Adults with right-sided endocarditis caused by Staphylococcus aureus
- Adults with Staphylococcus aureus bacteremia
For comprehensive details on the indications, please refer to the information for healthcare professionals.
Daptomycin® Rokitan: Possible side effects
Headache, nausea, vomiting, diarrhea, muscle pain, fungal infections, rash, abnormal liver enzyme levels and elevated creatine phosphokinase (CPK) levels. For further possible side effects and interactions with other medicinal products, please refer to the information for healthcare professionals.